Tesofensine

Triple monoamine reuptake inhibitor with strong appetite-suppressant effects.

Typical dose range: 0.25–1 mg

Frequency: Daily

Route: Oral

Half-life: ~9 days

Evidence level: Phase 3

Overview

Originally developed for Parkinson's, repurposed for obesity. Powerful weight loss but stimulant-class side effects (BP, HR, sleep).