Retatrutide

Triple agonist (GLP-1 / GIP / glucagon) showing the deepest weight reductions yet seen in Phase 3.

Typical dose range: 2–12 mg

Frequency: Weekly

Route: Subcutaneous

Half-life: ~6 days

Evidence level: Phase 3

Overview

Lilly's investigational triple agonist. Reported up to ~24% body-weight reduction at 48 weeks. Still investigational — research only.