Palmitoylethanolamide (PEA)

Endogenous fatty-acid amide with anti-inflammatory and analgesic effects.

Typical dose range: 300–1200 mg

Frequency: Daily

Route: Oral

Half-life: ~2 hours

Evidence level: Moderate

Overview

Well-tolerated nutraceutical with growing clinical evidence for neuropathic and inflammatory pain. Often stacked with luteolin for absorption.