First-generation daily GLP-1 with a long real-world safety record.
Typical dose range: 0.6–3.0 mg
Frequency: Daily
Route: Subcutaneous
Half-life: ~13 h
Evidence level: Strong (FDA-approved)
Sold as Victoza and Saxenda. Largely overshadowed by semaglutide and tirzepatide but still relevant where weekly dosing isn't tolerated.