Exenatide

Original short-acting GLP-1 agonist — twice-daily dosing.

Typical dose range: 5–10 mcg

Frequency: Twice daily

Route: Subcutaneous

Half-life: ~2.4 hours

Evidence level: Strong (FDA-approved)

Overview

Marketed as Byetta. Largely superseded by weekly GLP-1s, but still used clinically. Once-weekly extended-release version exists as Bydureon.